Press release summary
Promega has launched the Paradyme 27GY STR System, a forensic DNA amplification kit using an engineered polymerase intended to reduce stutter artifacts before capillary-electrophoresis analysis.
The eight-dye multiplex includes 23 autosomal short tandem repeat loci, Amelogenin, and selected Y-STR loci. It supports the expanded U.S. CODIS framework and is designed for Promega’s Spectrum and Spectrum Compact capillary-electrophoresis systems. Internal quality-indicator peaks are included to help laboratories distinguish amplification inhibition from sample degradation.
Promega reported an average eightfold reduction in stutter-signal intensity compared with current systems. The company said the reduced artifacts can improve contributor-count estimates and detection of minor contributors in mixed samples. Those performance claims are based on company studies and should be evaluated under each laboratory’s casework conditions.
Why it matters for laboratories
Stutter peaks complicate forensic mixture interpretation and can increase analyst review time. Reducing the artifact at amplification could simplify both manual assessment and probabilistic-genotyping workflows. Adoption would still require internal validation covering sensitivity, mixtures, degraded and inhibited samples, contamination controls, software compatibility, interpretation thresholds, and analyst training.
Original source: Promega release, Sept. 29, 2026.
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