Meet Sierra BioSystems at OTS 2026 in Denver, October 11–14
Sierra BioSystems is heading to the 22nd OTS Annual Meeting in Denver, Oct 11–14, 2026, with a new instrument to show. No booth, no queue —…
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Trityl Monitoring in Oligo Synthesis: What Matters for Yield
The trityl trace is the only real-time readout of coupling efficiency in oligo synthesis. How to read it, what it can't tell you, and how to…
DNA vs RNA Synthesis: What Actually Changes on the Instrument
RNA's 2'-OH protecting group causes steric hindrance. Here's how coupling times, amidite concentration, activators, and deprotection change on the synthesizer.
How the Shasta Cuts Oligo Synthesis Reagent Consumption
In high-throughput, plate-based oligonucleotide synthesis, reagents — especially acetonitrile (ACN) and amidites — are one of the largest recurring costs. The Sierra BioSystems Shasta was engineered…
Bringing Oligo Synthesis In-House: A Real TCO Breakdown
In-house vs. outsourced oligo synthesis: a true total-cost-of-ownership breakdown of reagents, labor, instrument amortization, and where the break-even sits.
Understanding V2 Values on the K&A Trityl Monitor
If you run a K&A synthesizer, the trityl monitor gives you a live readout of how well each coupling is going — and the single number…
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